Spear N, Gadient RA, Wilkins DE, Do M, Smith JS, Zeller KL (2010)
A kinetic view of GPCR allostery and biased agonism
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In particular, TeSLA is capable of measuring different cellular subpopulations in peripheral blood mononuclear cells, e.g., CD28() T cells, which have a limited capability for cell division, shorter telomeres, and more high rate of telomere shortening relative to other subtypes of mononuclear cells (Weng et al., 2009)
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A: Degradation can sometimes be detected by changes in the appearance of the peptide solution (e.g., cloudiness, precipitation) or a loss of expected biological activity