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This review aims to provide references for developing novel therapeutics targeting the DAMP/PRR signaling axis, potentially opening new treatment avenues for cancer, neurodegenerative diseases, cardiovascular diseases and inflammatory disorders

(89), through a 60-day prospective, experimental, controlled, double-blind study with 60 patients diagnosed with chronic migraine, predominantly women, observed that omega-3 PUFAs intake led to a significant reduction in headache days, indicating the benefit of omega-3 PUFAs in migraine prophylaxis

In addition, leptin administration reverses the effects of sustained weight reduction on energy expenditure 2, 4

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