Older adults or those with reduced physiological reserve may benefit from a more cautious escalation approach
Gastrointestinal side effects are the most frequently reported adverse reactions to GLP-1 receptor agonists, affecting a significant proportion of patients, particularly during initial treatment or dose escalation
GLP-1 provides powerful appetite suppression and gastric slowing
doi: 10.3109/07420528.2014.897711 29 MochelJPDanhofM
use with caution in renal impairment), folate (cell division), zinc (immune function, wound healing), and vitamin C (immune support, iron absorption)
Creatine supplementation may support muscle preservation during GLP-1 therapy, with evidence suggesting modest benefits for strength and lean mass retention