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This hormone helps regulate appetite, insulin secretion, and gastric emptying after meals

Semaglutide and other GLP-1 medications slow gastric emptying, which can complicate anesthesia delivery and postoperative recovery

The JNK pathway can regulate the function of autophagy by affecting several key proteins (98)

Rule of thumb: most weight-loss guidelines suggest that a daily deficit of around 500 calories may lead to gradual weight loss of approximately 0.40.5 kg per week, although results vary depending on metabolism, activity levels and dietary habits

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The slowdown is particularly dramatic when someone first starts on a GLP-1, which is why they may be particularly sensitive to nausea from high-fat foods during this period