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Its discovery stemmed from research into organ protection, and it quickly became apparent that its therapeutic activities were far-reaching

The stage 3a threshold aligns with the renal-protective findings of the FLOW trial, which demonstrated meaningful kidney protection from semaglutide in adults with type 2 diabetes and CKD

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Additionally, we examine current clinical trials and discuss existing gaps and opportunities that warrant further consideration

New therapies such as nerve blocks, mesenchymal stem cell injections, platelet-rich plasma injections, and osteoporosis medications like strontium ranelate offer additional options for OA management