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Third, the most plausible blueprint for a cure involves intelligent Combination Strategies, designing synergistic treatment protocols where a finite course of immunotherapy is deployed to establish a receptive, tolerant immune environment, thereby facilitating the successful engraftment and persistence of gene-edited, immune-resilient beta cells

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In the first two studies, changes in redox and methylation metabolism were reported but because the studies were open-label the changes in these biomarkers were not compared to a placebo group

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