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4 Hyperandrogenism, ovulatory function, and fertility outcomes: a reproductive perspective 4.1 Remodeling of the androgen profile and endocrine homeostasis Hyperandrogenism is a hallmark phenotype of PCOS, serving as the link between metabolic derangement and ovulatory dysfunction via the insulinovaryhepatic SHBG axis

Plus, they experienced enhanced insulin secretion and sensitivity by the end of those 88 weeks too, suggesting tirzepatide may help regulate blood sugar levels

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Levy also expressed concern that it could cause weight cycling, or yo-yo dieting repeatedly losing and gaining weight, which can have negative health consequences like a higher risk of dying suddenly from a heart attack