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Multiple randomized controlled trials show that adding semaglutide to existing metformin therapy produces 15-25% greater weight loss than either medication alone

Omeprazole and other PPIs reduce dietary B12 absorption (less critical with nasal forms but still relevant to overall status)

Thus, as predicted by RNA-Seq, leptin and CCK signaling was compromised in Bbs5 / mice, which may explain at least in part the hyperphagic phenotype in BBS

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