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Research and clinical trials provide a mixed perspective on this matter

From the absolute values of GSH and GSSG, we estimated the redox potential of the GSSG/2GSH redox couple using the Nernst equation (see Methods)

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In AN patients and in rodent AN models, chronic food restriction induces profound alterations in the ghrelin signaling that leads to the development of inappropriate behaviors like hyperactivity or addiction to food starvation and therefore a greater depletion in energy reserves

Mitochondrial dynamics in neurodegeneration