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Reperfusion injury is characterized by increased oxidative stress, which damages cardiomyocytes, endothelial cells, and the extracellular matrix [90]
The article lists fasting glucose above 100 mg/dL as suggesting prediabetes and above 126 mg/dL as indicating diabetes, HbA1c above 5.7 percent and 6.5 percent for the same two categories, and fasting insulin above 12 microunits per milliliter as suggesting resistance
Treatment induces p53-pS15 nuclear exclusion, triggering the apoptotic cascade specifically in senescent fibroblasts while sparing healthy cells
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