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Im not sure if its related, but the timing seems to coincide. While the exact mechanism behind the link between glutathione and headaches is not yet fully understood, it is thought to be related to changes in blood flow and intracranial pressure

Relative to the control values, a significantly higher blood volume loss sustained before the death (which is dose-dependent) was consistently noted in CaBPC157 treated rats

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Glutathione is produced by every cell of the body, with especially high levels in the liver