tirzepatide google scholar outcompetes long-acting insulin in managing type 2 diabetes: a meta-analysis of three phase 3 randomized controlled trials Effect of tirzepatide versus insulin

His protocol: tirzepatide (Mounjaro) at 2.5mg/week, half the lowest standard pen dose, with targeted resistance work to protect muscle

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Sample sizes were 6-14 subjects

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A larger phase 2b trial by Metabolic Pharmaceuticals (the original sponsor) in 2007 with 534 obese patients failed to show statistical superiority over placebo at 24 weeks

Xenobiotica 1996