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Personalised dietary strategies are particularly relevant considering that, although generally well tolerated, GLP-1RA may cause transient gastrointestinal (GI) symptoms that can hinder adherence if not properly managed [27]
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These compounded preparations are subject to different regulatory standards than FDA-approved manufactured drugs
Depending on the formula, both semaglutide and tirzepatide medications are FDA-approved for either weight loss or type 2 diabetes treatment
GLP-1 Receptor Agonists (e.g., semaglutide, liraglutide) Increase insulin secretion in response to food Reduce glucagon release (which lowers blood sugar) Slows gastric emptying (which helps with post-meal glucose excursions) Reduces appetite and induces satiety which leads to weight loss GLP-1/GIP Receptor Agonists (e.g., tirzepatide) GLP-1 effects (same as above) GIP effect: further enhances insulin secretion Both medications help with blood sugar control and weight loss, but Mounjaros dual mechanism may offer stronger effects on insulin secretion, which improves A1c levels
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