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STAT3 is a crucial factor in maintaining cell proliferation and survival, and can be activated by various cytokines to mediate immune and inflammatory responses (Wu X

Elevation of 2 C in the BAT skin area following 1-week G49 treatment was found in parallel with an increase in thermogenic-related genes ( Cpt1b , Dio2, CoxIVi1, Ucp1, Th, Fgf21 ) and protein levels of UCP1 and TH in BAT (Fig

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These may indicate serious bleeding or liver complications requiring urgent medical attention

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Patients on GLP-1 therapy often remain in a low-grade inflammatory state during the active weight loss phase, which can slow the very tissue remodelling that would otherwise benefit from reduced adiposity