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Gclc f/f mice 27 were crossed with the MMTV-PYMT (The Jackson Laboratory, 022974) 61 and Rosa26 creERT2 (The Jackson Laboratory, 008463) 62 mouse strains

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10.3389/fcimb.2022.845580 Front

The genetic risk conferred by HLA class II molecules, the accumulation of chronically activated T cells in the diseased joint and the T-cell dependence of autoantibody production all support a critical role of dysfunctional memory T cells as a salient feature of RA

In recent decades, research has expanded into regenerative and anti-inflammatory peptides