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10 Conclusions and future directions While the existence of physical stimuli within the breast tumor microenvironment and throughout the metastatic cascade has been acknowledged for several decades, our understanding of their role in breast cancer remains incomplete

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10.1016/j.aquaculture.2019.01.033

These aged cells harm your skin in two ways: They stop working - Senescent fibroblasts no longer make collagen and elastin, which leaves skin unable to repair damage effectively [19] They cause inflammation - These cells develop a "senescence associated secretory phenotype" (SASP) that triggers inflammation and breaks down skin structure [20] Low NAD+ speeds up senescence by reducing SIRT1 activity, which lowers p63 expression and cell growth [19]

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10.1039/c9fo00298g [DOI] [PubMed] [Google Scholar] 87.Shimoi K, Nakayama T