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In a randomized, double-blind, placebo-controlled trial, liraglutide significantly decreased the proinflammatory cytokine IL-6 with similar trends for other proinflammatory cytokines in humans [97]

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15 A 2023 study found that patients with cognitive impairment who received active B12 (methylcobalamin + adenosylcobalamin) showed significant improvement in cognitive assessment scores after six months compared to controls

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