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Morning versus evening injection Clinical trials show no statistically significant difference in weight loss outcomes between morning and evening GLP-1 injections

Common side effects include: Nausea and vomiting Digestive issues like diarrhoea, constipation, or abdominal pain Headaches and fatigue Injection site reactions Serious but less common side effects: Pancreatitis Gallbladder problems Kidney problems Low blood sugar Most gastrointestinal side effects settle within the first month or two

16 However, there have been reports of injection site discomfort from those new to injecting GLP-1s

What do these trial results mean in practical terms

For patients with clinically low testosterone, hormone optimization through TRT can further improve the ratio of fat lost to muscle preserved

Long-term safety remains an open question