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Clinically, elevated IS levels correlate strongly with increased cardiovascular event incidence in patients with CKD, primarily mediated by inducing oxidative stress in endothelial cells (Lin et al., 2012

These membranes underwent a 1-h incubation in a 5% skim milk blocking solution, followed by an overnight primary antibody challenge at 4 C using the following specific targets: Claudin-1 (ab317709), Occludin (ab216327), COX-2 (ab283574), and GPX4 (ab125066), all sourced from Abcam

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Fasting glucose and HbA1C both decreased more than twice as much in those receiving lorcaserin than placebo (ONeil 2012)

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