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The dosing of bupropion in Contrave is lower than typical antidepressant dosing, so a direct switch isnt straightforward

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Nausea, constipation, diarrhea, and mild stomach discomfort can occur, especially at the start of treatment

J Biol Chem 278:24150, PMID: 12414812 Day RM, Suzuki YJ (2006) Cell proliferation, reactive oxygen and cellular glutathione

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