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CFTR participates in spermatogenesis, and evidence suggests its involvement in seminiferous intratubular fluid control, maintenance of the bloodtestis barrier, and improvement in follicle-stimulating hormone signalling, among other functions

39,43,46,47,48 Dosages used have ranged from 800 to 2000 mg per day in longer-term studies (212 weeks), with the highest dose seeing the largest reductions in homocysteine

doi: 10.1073/pnas.91.21.10114