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Glutathione synthesis requires adequate levels of cysteine (often the limiting factor), glutamic acid, and glycine

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Interestingly, CD8 + T cells compensatory upregulate the Gln transporter ATB + /SLC6A14 to maintain their Gln uptake requirement after treatment with V-9302, but this phenomenon was not observed in tumor cells

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Researchers examine how ERR activation affects ATP production, oxidative stress resistance, synaptic plasticity, and cognitive performance in experimental systems focused on brain energy metabolism and neuronal function