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Consistent with the results of the parent trial, a favorable treatment effect on cognition was observed in substudy participants (P = .03)

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Lipid rafts (or cholesterol-rich nanodomains) are regions within the plasma membrane where weak binding between cholesterol and other phospholipids allows specific protein interactions to occur (Saxena and Chattopadhyay, 2012), as well as for effective serotonin control of food intake and prevention of hyperphagia (van Galen et al., 2021)

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Downstream analyses of count data were performed with Seurat v4.3.0

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