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In a 68-week clinical trial, patients treated with GLP-1 experienced an average weight loss of 14.9% from their initial body Trusted Source Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial Rubino D, Abrahamsson N, Davies M, et al Go to Source weight

This hormonal dysregulation means patients often struggle with appetite control independently of calorie awareness

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This could lead to more weight loss if not managed carefully

This promotes insulin secretion, improves insulin resistance, and inhibits lipogenesis which is associated with changes in the composition of the gut microbiota and its metabolites [( 3.1.1