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Metformin is a clinically approved drug used for the management of type II diabetes (24), and has been demonstrated to act as an inhibitor of oxidative phosphorylation, through inhibition of complex I of the Electron Transport Chain (ETC) (25, 26)

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Estimated plasma half-life is approximately 2 hours, though precise human pharmacokinetic data remain limited and are largely extrapolated from animal and in vitro systems

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