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SCF FBXO22 -Degrader-NSD2 PWWP1 ternary complex formation for cryo-EM Formation of the SCF FBXO22 -UNC10088-NSD2 PWWP1 and SCF FBXO22 -UNC10415667-NSD2 PWWP1 ternary complexes was performed by incubating SKP1-FBXO22, CUL1-RBX1, NSD2 PWWP1, and UNC10088 or UNC10415667 at a 1:1:1:1 molar ratio for 4 h on ice