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Appl Sci (2021) 11:11031

There are reports on PKA-independent activation of GLP-1 via PLC/PKC pathway 1

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Metabolic stress, calcium dysregulation and neuroinflammation mediated by glial cells like astrocytes and microglia further exacerbates RGC loss ( In many eye diseases, oxidative stress and mitochondrial dysfunction are key contributors to RGC degeneration

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