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Evening dosing also shifts peak appetite suppression into early morning and midday hours, which can benefit people who struggle most with breakfast or lunch appetite control
Any future oral formulation would likely share similar systemic effects, though the gastrointestinal profile might differ
If there is presence of enzymatic activity and/or spontaneous oxidation in storage, we would expect to observe lower levels of total GSH and free GSH, and elevated levels of GSSG, in the EDTA-treated sample stored at 4 o C compared to the non-deproteinized EDTA-treated plasma stored at 80 o C
However, the relevance of these findings to humans remains uncertain because human thyroid C-cells express GLP-1 receptors at much lower levels than rodent C-cells, suggesting potentially different susceptibility to GLP-1-mediated effects
Over the past couple of years, you looked at the private credit market in depth and that's where I think the exposure we found is the highest in BDCs, you know, which is the public face of private credit