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Depending on their subtype, TAMs can produce either pro-inflammatory cytokines (e.g., IL-1 and IL-6) or anti-inflammatory cytokines (e.g., IL-4 and IL-10), thereby modulating the cytokine profile and shifting the tumor microenvironment toward either tumor suppression or tumor promotion (91)

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In doxorubicin-induced cardiotoxicity, FNDC5/irisin alleviates oxidative stress and cardiomyocyte apoptosis by activating AKT/mTOR signaling and the AKT/GSK3/FYN/Nrf2 axis [197]

The List outlines the substances and methods that are prohibited: At all times (both in- and out-of-competition), or Only in-competition, or In particular sports