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To achieve approval, the medication had to be carefully evaluated by a team of experts to determine that the benefits outweigh the risks for the intended population when used to treat a specific condition

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and 2% internationally in 2025

Some patients experience mild nausea during the first one to two weeks as their digestive system adjusts and appetite signals change

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NEJM 2025 (REDEFINE-2) Novo Nordisk FDA NDA submission announcement (December 18, 2025) Eli Lilly TRIUMPH-4 topline results (December 2025) Frequently Asked Questions Retatrutide produces higher weight loss at 28.7% versus CagriSema's 20.4%a difference of 21 pounds for a 250-pound person