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Organizations involved: pharmaceutical R&D teams (Novo Nordisk, Eli Lilly), biotech startups, academic labs, specialized formulation companies, contract research organizations (CROs) for preclinical work, and CMC/CDMO partners for scale-up

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Central to this axis is the gut microbiota, which plays a pivotal role in maintaining homeostasis across the gastrointestinal, neurological, and renal systems

In adipocytes, preferential routing of glucose towards lactate production and citrate export for lipogenesis limits succinate flux through CII, which may bias electron entry towards CI 44,45

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