Additional assay details are provided in Additional file 1
In the lungs, after entering in type II alveolar cells, SARS-CoV-2 infected cells become defective for surfactant production (Ghati et al., 2021) and release cytokines, like IL-8 among others, which in turn activate alveolar macrophages to release IL-1, IL-6, and TNF-, that induce natural killer and dendritic cell differentiation and macrophage M1 polarization, enhancing the proinflammatory response with increased vasodilation causing neutrophil and activated T cell influx from the capillaries into the alveolus, all leading to the cytokine storm (Carcaterra and Caruso, 2021
Quesnel-Vallieres, M
The Hayflick limit describes the finite number of divisions that a normal somatic cell can undergo in culture before it enters senescence
It is considered an intermediate in the transformation pathways of phosphorylated thiamine derivatives [10]
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
