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The biggest controversy surrounding GLP-1 drugs is whether they cause excess muscle loss We now have an answer: "No." Compared to weight loss by diet or surgery, GLP-1RA-induced weight loss is comparable in its effects on lean body mass

For the individual compound, see our Ipamorelin FDA approval status guide

Extreme weight loss is not a medically desired effect

GLP-1 and the cardiovascular system

For those weighing retatrutide against other options, the semaglutide vs tirzepatide comparison provides useful context, as does the retatrutide vs tirzepatide dosage chart for side-by-side dose analysis

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