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Because the therapeutic potential of supplemental coenzyme Q 10 is limited to its capacity to restore electron transfer in a defective mitochondrial respiratory chain and/or to increase antioxidant defense, patients with secondary coenzyme Q 10 deficiency may fail to respond to supplementation (see Disease Treatment)

Guidance document for the use of adverse outcome pathways in developing integrated approaches to testing and assessment (IATA)

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doi:10.1016/j.bcp.2017.11.007

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