Dai X, Dharmage SC, Bowatte G, Waidyatillake NT, Perret JL, Hui J, et al
A 2024 trial found a cream with 5% alpha-arbutin and 2% kojic acid worked about as well as a prescription melasma cream but with fewer side effects
Maximum AHK-CU Concentration The general consensus in peptide formulation is that 10% is the maximum concentration for topical copper peptide use
Functions of Glutathione Glutathione plays a multifaceted role in the body, supporting various essential functions: Neutralizes Free Radicals Protects cells from oxidative damage caused by pollution, UV radiation, and stress
Most common side effect are vomiting & mild anaphylactoid reactions Tx these with reducing rate of infusion and antihistamines Rare severe anaphylactic reaction, tx by usual kitchen sink approach (fluids, stop drug, epi to support hypotension, antihistamines, steroids) Note*** as per Jesse: PO NAC is essentially never used in a Canadian context more of an American thing.Interestingly anaphylactoid reactions are more common in patients with negative acetaminophen levelsSee Table 143.3 for Side effect profile for NAC formulations [7] Describe a NAC protocol for IV administration *** Always check with your local institutions protocol and always call your local tox centre!*** As seen on LITFL: Adult dosing: Give 150 mg/kg NAC diluted in 200 ml of 5% dextrose IV over 15-60 minutes
Follicle Size and Anagen Extension In a 1993 study by Pickart and colleagues, topical GHK-Cu applied to mice with surgically induced wounds significantly increased hair follicle size and triggered follicles from telogen back into anagen
