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A human RCT from Wuhan, China, showed that ALA therapy (1200 mg/d) for 7 days, could reduce a 30-day all-cause mortality rate (37.5%) in critical COVID-19 patients 535

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The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible

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[61], LBPs were used as an adjuvant to lymphokine-activated killer (LAK) cells and IL-2 therapy in patients with various cancers, including malignant melanoma, lung cancer, renal cell carcinoma, and colorectal carcinoma