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The Fuzi study in a cold-damp CIA model demonstrated that donor FMT transferred efficacy, accompanied by elevated bile acids like TCA and THDCA and changes in bile acid signaling-related pathway readouts (e.g., TGR5-cAMP-PKA axis and NLRP3-related readings) ( Level C Consistency Supplement: Multiple Level C studies indicate broad-spectrum metabolic dysregulation in RA models, with treatment driving regression toward a healthy state across multiple pathways, paralleling microbiota structural improvement and inflammation reduction
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The FDAs decision will ultimately determine whether BPC-157 gains a pathway for traditional compounding, and providers should continue monitoring the agencys next steps while maintaining an evidence-based approach to patient care
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