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Mechanisms of endothelial dysfunction: clinical significance and preventive non-pharmacological therapeutic strategies

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Hypoxia-inducible factor modulates tubular cell survival in cisplatin nephrotoxicity

GSTP1 polymorphism: A potential biomarker for cancer risk It has been demonstrated that GSTP1 enzymatic activity is strongly dependent on a single-nucleotide polymorphism, the A313 G polymorphism, which replaces isoleucine (Ile) with valine (Val) at the 105 amino acid position (Ile105Val) (IE), producing three GSTP1 genotypes: Ile/Ile homozygous wildtype, Ile/Val heterozygotes, and Val/Val homozygous variants (108,109)