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For example, type 2 diabetes has well-documented mitochondrial oxidative stress, accompanied by depleted or oxidized GSH levels

Chosen because they exhibit accelerated biological aging, characterized by premature onset of age-related conditions, persistent low-grade inflammation, and metabolic dysfunction, that cohort was uniquely suited for the experiment, the paper suggests

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GLP-1 AND GIP RECEPTORS SIGNAL THROUGH DISTINCT -ARRESTIN 2-DEPENDENT PATHWAYS TO REGULATE PANCREATIC CELL FUNCTION GLP-1 (glucagon-like peptide) and GIP (glucose-dependent insulinotropic polypeptide) are two metabolic hormones stimulating insulin secretion via activation of their respective G protein-coupled receptors (GPCRs) (GLP-1R and GIPR)

Arch Endocrinol Metab (2016) 60(4):32832