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In this aspect, astrocytic terminal processes, known as endfeet, contact the brain vasculature and enwrap the neuronal synapses, enabling the modulation of both neuronal activity and cerebral blood flow, following an elevation in intracellular Ca 2+ levels in the endfeets [24,29]

Cardiovascular signal Gabe et al

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The injectable route makes more sense for wound healing and skin remodeling protocols where systemic distribution is the goal