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Research Overview Retatrutide (LY3437943) is a first-in-class triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously

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When food enters the digestive system, GLP-1 is released and acts on multiple targets: it stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

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31.5% placebo