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These benefits were highlighted in 2019 when the Lancet published a meta-analysis of seven clinical trials showing that these treatments reduced hospital admission by 9%, all-cause mortality by 12% and deaths associated with kidney disease by 17% (Wilding et al., 2021)

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While the low starting dose of 0.25 mg is specifically designed to mitigate these adverse effects, many patients will still experience some mild discomfort as their system adapts

These changes happen because corticosteroids can influence chemicals in the brain