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Could the authors clarify how controls were selected and whether analyses were adequately adjusted for baseline maternal BMI

That dual mechanism is what makes it more effective than semaglutide in head-to-head trials, but it also means the gastrointestinal adaptation period can be significant

Nle represents norleucine, a nonnatural amino acid substitution

In the PIONEER 4 trial, 14 mg daily doses led to A1C reductions of 1.2%-comparable to Ozempic at standard doses