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If you have been vomiting or had diarrhea, you also lose salts, not just water, so a drink with some electrolytes can help on rough days

It means that to achieve the same systemic exposure as a 1mg injectable dose, you might need a 10mg oral dose

PMID 22892942

Contrave is an oral tablet combining Naltrexone and Bupropion that targets brain pathways tied to cravings, while Ozempic is a once-weekly Semaglutide injection that mimics a gut hormone to reduce appetite and slow digestion

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These differences translate to weekly dosing for semaglutide versus daily for liraglutide, and approximately double the weight loss efficacy in head-to-head trials