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These peripheral pro-inflammatory cytokines, including IL-8 and TNF-, are also elevated in brain tissue and cerebrospinal fluid, suggesting that systemic inflammation may influence central nervous system (CNS) function either through blood-brain barrier (BBB) leakage or active transport (Matta et al., 2019

Its primary physiological role involves stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner, which has made GLP-1 receptor agonists valuable therapeutic agents for type 2 diabetes mellitus

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Most over-the-counter and prescription sleep aids are compatible with GLP-1 medications, but always consult your provider before combining medications to avoid interactions