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While a similar trend was observed between tissue type, with metastatic tissue having decreased immune-cell infiltration when compared to primary tissue, immune cell type enrichment consistently differed between primary and metastatic comparisons and high and low GLP-1R comparisons, suggesting a subgroup-specific pattern of immune modulation

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Multivariate analysis of fasting glucose showed that fasting glucose was lower in the placebo arm at 12 months (2.2 mmol/L 95%CI: 0.4, 4.1, p = 0.027) but not at 6 months (1.4 mmol/L, 95%CI 1.1, 3.9, p = 0.24) (Supplementary Tables 10.1 and 10.2)