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10.1038/mp.2017.65 79

From a mechanistic perspective, iodine status creates a U -shaped risk curve for neurological outcomes: insufficient intake undermines hormone synthesis and cognitive capacity, while excess fosters autoimmunity and inflammatory cascades (145)

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RNA-seq and subsequent gene set enrichment analysis (GSEA) revealed that the liver tissue from Gclc KO mice was enriched in several gene signatures associated with stress responses, including those related to the activation of NRF2 (Fig