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A neurosurgical piston with a graduated force of 6066 g was placed over the exposed dura and left for 60 s to induce a compression injury

10.1513/pats.200909-099RM

Active mTORC1 phosphorylates downstream effectors including p70S6K and 4E-BP1, which together increase ribosomal biogenesis, enhance mRNA translation, and drive protein synthesis - the fundamental process underlying muscle hypertrophy and tissue regeneration