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XG and XH performed the literature search, extracted the data, analyzed the data, and wrote the manuscript
Significant changes in TCA intermediates fumarate and succinate, and in the secondary TCA metabolites succinyl-carnitine and methyl succinyl-carnitine were observed, arguing that the potential anti-inflammatory properties of these metabolites are mediated by metabolic rewiring
Nighot M, Liao PL, Morris N et al (2022) Long term use of proton pump inhibitor disrupts intestinal tight junction barrier and exaggerates experimental colitis
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Signs youre managing well enough to continue: Youre drinking fluids regularly without vomiting You can eat small, frequent meals or snacks Your symptoms are improving or stable, not worsening Youre able to rest and recover at home No signs of dehydration (dark urine, dizziness, rapid heartbeat) Consulting Your Healthcare Provider Before making any decision to skip doses, contact your healthcare provider
These results persisted through 12 months
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