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Oral supplements in this range are generally safe because excess B12 is water-soluble and excreted through urine, making toxicity extremely rare

Journal of Strength and Conditioning Research, 21(1), 259265

[39] These allergic reaction-like symptoms, which typically occur within 3060 minutes of ingesting alcoholic beverages, do not appear to reflect the operation of classical IgE- or T cell-related allergen-induced reactions but rather are due, at least in large part, to the action of acetaldehyde in stimulating tissues to release histamine, the probable evoker of these symptoms

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